What are the Symptoms of Primary Ovarian Insufficiency?

The symptoms of primary ovarian insufficiency can vary from person to person but commonly include:

Irregular or Absent Menstrual Periods: Changes in the menstrual cycle are often one of the earliest signs.
Hot Flashes and Night Sweats: Similar to menopausal symptoms, women with POI can experience these due to hormonal changes.
Difficulty Conceiving: Infertility or difficulty getting pregnant is a significant symptom.
Vaginal Dryness and Painful Intercourse: Decreased estrogen levels can cause vaginal dryness and discomfort during sex.
Mood Changes: POI can affect mood, leading to irritability, anxiety, or depression.

This information does not constitute medical advice or diagnosis.

Primary ovarian insufficiency (POI), also known as primary ovarian failure, is a rare condition that occurs when the ovaries stop working before age 40. Symptoms of POI include:

Infertility
Irregular menstrual cycles
Vaginal dryness
Irritability

However, some women with POI don’t have any symptoms.

The most common treatment for POI is hormone therapy (HT).

HT provides the body with estrogen and other hormones that the ovaries aren’t producing. HT can improve sexual health and reduce the risk of heart disease and osteoporosis. It’s usually taken until around age 50, when menopause typically begins.

POI is often caused by chromosomal abnormalities or damage from chemotherapy or radiation therapy. It can also be associated with a premutation in the FMR1 gene for fragile X

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