Repeated implantation failure is a condition where a woman undergoing IVF treatment fails at least three times in spite of quality embryos. It is a condition of concern to fertility specialists worldwide. Endometrial tolerance to the embryos is an important factor in the treatment cycle. Defects in receptivity contribute to repeated implantation failure. Low receptivity can be due to thin endometrium, decreased blood flow, reduced regulatory molecules and fewer receptors like pinopods.
Therapies currently used for patients of RIF to enhance endometrial receptivity.
- Higher doses of estrogen, longer period of endometrial stimulation.
- Low molecular weight heparin
- Aspirin
- Vitamin E
- Stem Cells and Granulocyte Colony-Stimulating Factor
- (G-CSF)
- Growth Hormone (Gn),
- Biofeedback (BF)
- Platelet-rich plasma (PRP)
- Traditional Chinese Medicine (TCMs) derived from placenta
- Acupuncture
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