In the IVF cycle your doctor will hyperstimulate the ovaries to retrieve multiple eggs. In this process a lot of estrogen hormone is released by the ovaries. Due to this higher level of hormone your endometrium grows faster than usual and attains abnormally advanced maturity. This creates asynchrony between embryo and endometrium leading to failure of implantation. Endometrium scratching delays the growth of uterine lining by producing injury. It promotes wound healing by releasing various growth factors. In addition, these factors increase the blood flow to endometrium. Adequate blood flow to endometrium prevents embryo rejection.
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