When immunological causes for unsuccessful embryo implantations are suspected, PLI (LIT) Therapy is frequently carried out. It is thought that because the developing embryo and foetal tissues are produced from both the mother and father’s DNA, the mother’s immune system mistakenly views proteins formed from the husband’s share of the genome as foreign and attacks the developing baby. Paternal Lymphocyte Immunization (PLI) was created to make the mother’s immune system ready for pregnancy so that it can help acclimate the potential mother’s body to foreign cells rather than fighting and destroying the embryo or foetus.By introducing paternal proteins, antigens, and cellular structures to the developing embryo or foetus in a “friendly” manner before they may be deemed toxic and lead to the termination of early pregnancy, PLI Therapy is expected to alleviate this detrimental reaction.
