The precise causes of POI are not always known, but several factors can contribute to its development:
- Genetic Factors: Certain genetic disorders can cause POI or make a person more susceptible to developing it.
- Autoimmune Disorders: The immune system may mistakenly attack the ovaries, disrupting their function.
- Chemotherapy and Radiation: Cancer treatments like chemotherapy and radiation therapy can damage the ovaries, leading to POI.
- Ovarian Surgery: Surgical procedures involving the ovaries may inadvertently cause damage, affecting their functionality.
- Toxins and Environmental Factors: Exposure to certain chemicals or environmental toxins can also play a role in the development of POI.
Primary ovarian insufficiency (POI) is also known as premature ovarian failure. It’s a condition where a woman’s ovaries stop working normally. POI is often caused by:
- Chromosomal abnormalities
- Damage from chemotherapy or radiation therapy
- A premutation in the FMR1 gene for fragile X
- Autoimmune disease
- Eating disorders
- Psychological stress
Other causes of POI include: Genetic defects, Some surgeries, Injury.
POI is not reversible, but healthcare providers can treat symptoms, side effects, and associated conditions.