Who can benefit from Paternal Lymphocyte Immunization (PLI) Therapy?

PLI (LIT) Therapy in IVF is typically used following several unsuccessful IVF cycles and possible immunologic causes of poor implantation.A normal pregnancy would allow the foetus to grow in the mother’s uterus, and the growth would continue as an allograft that benefits from the foetus’ and mother’s immunological tolerance. However, there are instances where the mother’s immune system rejects the foetus. Primary RPL (Recurrent Pregnancy Loss) aborters and Secondary RPL aborters are the two basic categories into which recurrent pregnancy losses may be divided. The secondary RPL aborters have at least one normal pregnancy, but the primary aborters have no history of normal pregnancy. Hormonal, Metabolic, or Uterine abnormalities are a few of the main reasons, even if the cause may not be discovered in 50% to 60% of instances.

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